![]() This mechanism may enable the host to manipulate the gene expression and thereby the behavior of its bacterial colonizers. These results show that an animal manipulates bacterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacterial colonizers. Investigating the impacts of the different N-acyl-HSLs on host colonization elucidated that 3OHC12-HSL allows and 3OC12-HSL represses host colonization of Curvibacter sp. Mauras N., Mazaika P., Buckingham B., Weinzimer S., White N. Expression data revealed that Hydra’s main bacterial colonizer, Curvibacter sp., responds differentially to N-(3-hydroxydodecanoyl)- l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)- l-homoserine lactone (3OC12-HSL). L, Fromer M, Mazaika E, Vardarajan B, Italia M, Leipzig J, et al. with ventromedial prefrontal damage: a case of a modern-day Phineas Gage. We identified a eukaryotic mechanism that enables Hydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts. Englert K, Raman M, Jo B, Shen H, Reiss A, Mazaika P Diabetes Research in. Bruno, David Romano, Paul Mazaika, Amy A. Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensing signals. W Luo, MS Friedman, K Shedden, KD Hankenson, PJ Woolf, GAGE: Generally applicable. ![]() ![]() Several factors, including the innate immune system, mucus composition, and diet, have been identified as determinants of host-associated bacterial communities. There are 60+ professionals named 'Mazaika', who use LinkedIn to exchange information, ideas, and opportunities. Bacterial communities colonize epithelial surfaces of most animals. View the profiles of professionals named 'Mazaika' on LinkedIn. ![]()
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